WE ARE FIRST IN LINE TO GET STOCK!
PREPAID STOCK ORDERS AND PRIORITY LIST: To prepay for stock or to get placed on the priority list of call backs when new stock arrives please call TOLL FREE: 1-888-595-1393. How much stock is being created is unknown at this time therefore prepaid orders will be processed first before all others, then the non pre paid priority list will be served. Manufacturer's best estimate to get new stock is middle to end of March (times may vary).
PREPAID STOCK ORDERS AND PRIORITY LIST: will maintain your order in priority sequence once stock arrives. Please call TOLL FREE: 1-888-595-1393
Please Note: Be careful, there is unauthorized foreign B12 on the market, these items are not legal to buy or use. There are only two manufacturers licensed to manufacture B12 and both are out! We have been approached to sell these items and refuse as they are not safe! Our temporary solution until stock arrives is the Bioevolve B12 Sublingual Methylcobalamin
For Vitamin B12 Deficiency - B12 Nutritional Deficiency - Weight Control - Pernicious Anemia - Schilling Test
Vitamin B-12 is an important vitamin that you usually get from your food. It is mainly found in meat and dairy products. Vitamin B-12 helps make red blood cells and keeps your nervous system working properly.
*Due to an industry shortage of 30mL brown glass vials and to eliminate any downtime in supply, our manufactures have temporarily switched to a larger 50mL brown glass vial. These are bigger vials that may appear half full. But please be assured that there is 30mL of B12 in each bottle and there are no other differences.
***This item does not come with syringes or needles.***
This Vitamin B-12 shot can be used at home as an injection, under instruction of a doctor. Before using this medicine, a health care professional will provide detailed instructions for appropriate use of this medicine. Ask any questions that you may have about this medicine or giving injections. Store this medicine as directed. If you miss a dose of this medicine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
DO NOT TAKE large doses of vitamins (megadoses or megavitamin therapy) unless directed to by your doctor. DO NOT STOP USING THIS MEDICINE without first checking with your doctor. IT IS IMPORTANT that you keep all doctor and laboratory appointments while you are using this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist.
Rubramin PC® (Cyanocobalamin Injection) contains cyanocobalamin (vitamin B12) in a clear, red,sterile, nonpyrogenic, aqueous solution in a potency of 1000 mcg/mL (cobalt: 40 mcg/mL) for intramuscular use. Each mL of solution also contains 10 mg benzyl alcohol as a preservative and sodium chloride for isotonicity; pH has been adjusted between 4.5 and 7.0 with sodium hydroxide or hydrochloric acid.
Cyanocobalamin is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80). The vitamin B12 coenzymes are very unstable in light.
Vitamin B12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.
Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular sites of injection; the plasma level of the compound reaches its peak within one hour after intramuscular injection. Absorbed vitamin B12 is transported via specific B12 binding proteins, transcobalamin I and II to the various tissues. The liver is the main organ for vitamin B12 storage.
Within 48 hours after injection of 1000 mcg of vitamin B12, 50 to 98 percent of the injected dose may appear in the urine. The major portion is excreted within the first eight hours.
Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. Prompt parenteral administration of vitamin B12 prevents progression of neurologic damage.
The average diet supplies about 5 to 15 mcg/day of vitamin B12 in a protein-bound form that is available for absorption after normal digestion. Vitamin B12 is not present in foods of plant origin, but is abundant in foods of animal origin. In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including milk products or eggs).
Vitamin B12 is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium, and vitamin B12 enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins. A small amount (approximately 1 percent of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses. Oral absorption is considered too unreliable in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B12.
Cyanocobalamin is the most widely used form of vitamin B12, and has hematopoietic activity apparently identical to that of the anti-anemia factor in purified liver extract. Hydroxycobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure.
Rubramin PC is indicated for use as the flushing dose in the Schilling (vitamin B12 absorption) Test for pernicious anemia.
This preparation is contraindicated in patients who are sensitive to cobalt and/or vitamin B12.
Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12.
Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements
Doses of vitamin B12 exceeding 10 mcg daily may produce a hematologic response in patients who have a folate deficiency. Indiscriminate administration of vitamin B12 may mask the true diagnosis of pernicious anemia.
Vitamin B12 deficiency that is allowed to progress for longer than three months may produce permanent degenerative lesions of the spinal cord. Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B12 deficiency. Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B12, irreversible damage will result.
Patients with pernicious anemia have about three times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated.
Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12; this effect may be due to interference with erythrocyte maturation.
Most antibiotics, methotrexate, and pyrimethamine invalidate folic acid and vitamin B12 diagnostic microbiological blood assays.
Long-term studies in animals to evaluate carcinogenic potential have not been done. There is no evidence from long-term use in patients with pernicious anemia that cyanocobalamin is carcinogenic. Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with cyanocobalamin.
Pregnancy Category C. Adequate and well-controlled studies have not been done in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy. Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for pregnant women (4 mcg daily) should be consumed during pregnancy.
Vitamin B12 is known to be excreted in human milk. Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for lactating women (4 mcg daily) should be consumed during lactation.
Vitamin B12 appears in the milk of nursing mothers in concentrations that approximate the mother's vitamin B12 blood level.
Safety and effectiveness in pediatric patients has not been established.